Cellceutix Adds Brain Cancer to Growing List of Indications for its Novel Cancer Drug

BEVERLY, MA–(Marketwire – May 30, 2012) – Cellceutix Corporation (OTCBB: CTIX) (the “Company”), a biopharmaceutical company focused on discovering small molecule drugs to treat unmet medical conditions, including drug-resistant cancers, announced that its recent research has shown that its flagship anticancer compound Kevetrin™ has potent anticancer activity in malignant glioma (brain tumor).

Results from the Company’s latest in vitro research activities have shown that treatment of glioblastoma cell line (U-87 MG) with Kevetrin™ reactivates p53. The p53 signaling pathway is a crucial regulator of cell cycle and apoptosis. Remarkably, the p53 signaling pathway is defective in most, if not all, human tumors. In U-87 MG, Kevetrin™ activated p53 which induced the expression of p21 that acts as inhibitor of cell cycle progression. Activated p53 also triggered apoptosis by inducing expression of PUMA.

Glioblastoma joins the growing list of cancer types in which Kevetrin™ has potent anti-tumor activity, which already includes prostate, lung, breast, colon, head & neck, squamous cell carcinoma and a leukemia tumor model.

The Company would also like to inform shareholders that it has registered for the Rodman & Renshaw 14th Annual Healthcare Conference to be held at the Waldorf Astoria in New York, NY September 9 – 11, 2012.

“As the commencement of the clinical trials for Kevetrin™ draws near, we are aware of the need to inform the broader investment community of our progress,” said Leo Ehrlich, Chief Executive Officer at Cellceutix. “This will be our first global investment conference introducing Cellceutix to Institutional Investors, Venture Capital firms, Industry Executives, Private Equity firms and more. Barring any setbacks, we believe that the clinical trials will be well-underway by the Redman & Renshaw Conference. Given the p53 breakthrough and the recent industry focus on immunotherapies and T-cells in cancer research, we anticipate that the attention that we are already receiving will be amplified considerably as we discuss with large-scale investors how Kevetrin™ has taken immunotherapy and chemotherapy to a whole new level.”

About Kevetrin™As a completely new class of chemistry in medicine, Kevetrin™ has significant potential to be a major breakthrough in the treatment of solid tumors. Mechanism of action studies showed Kevetrin’s unique ability to affect both wild and mutant types of p53 (often referred to as the “Guardian Angel Gene” or the “Guardian Angel of the Human Genome”) and that Kevetrin strongly induced apoptosis (cell death), characterized by activation of Caspase 3 and cleavage of PARP. Activation of p53 also induced apoptosis by inducing the expression of p53 target gene PUMA. p53 is an important tumor suppressor that acts to restrict proliferation by inducing cell cycle checkpoints, apoptosis, or cellular senescence.  

In more than 50 percent of all human carcinomas, p53 is limited in its anti-tumor activities by mutations in the protein itself. Currently, there are greater than 10 million people with tumors that contain inactivated p53, while a similar number have tumors in which the p53 pathway is partially abrogated by inactivation of other signaling components. This has left cancer researchers with the grand challenge of searching for therapies that could restore the protein’s protective function, which Kevetrin appears to be doing the majority of the time.